My career has taken a non-conventional track as I left science for 12 years in 1984 to take care of my daughter who was chronically ill. When I returned it was necessary to retrain and to this end I undertook a Masters degree, which provided a stepping stone to return to the lab. I was subsequently awarded a 4 year Wellcome Trust Career re-entry grant which funded my postdoc. Skok JA. Taking a break from the lab: can it really be done? Trends Cell Biol. 2014 Dec;24(12):725-6. PubMed PMID: 25458041.
I received a highly competitive University Award, associated with a tenured position to start my own lab at University College London in 2002. Funding for my lab was supplemented with two consecutive Wellcome Trust Project grants (the equivalent of an NIH renewal. Details can be found on ORCID, see link below).
There is another gap in productivity from 2013 due to the disruption of Hurricane Sandy when my lab was shut down for ten months. We lost all our reagents and mice breeding was severely effected. We were fortunate in being offered space at the NYU Washington Square campus but our day-to-day research efforts were severely hampered as a result of being separated from the medical school where our mice are housed and where the FACs cell sorters are located. Furthermore, relocating our whole operation to Washington Square and back again ten months later caused additional disruption.
Expertise: My laboratory applies a combination of sophisticated imaging techniques, molecular biology, genetics, and immunology to investigate the contribution of nuclear organization and long-range interactions in coordinating transcriptional programs, recombinational events and the maintenance of genome stability in developing lymphocytes. Since starting my lab I have continued to pioneer new applications of 3-D FISH and have set up a highly innovative CRISPR/Cas9 live imaging system. I independently established chromosome conformation capture at NYU. In collaboration with Richard Bonneau’s computational biology group at NYU we developed a method for 4C-seq analysis, 4C-ker. In addition we developed 4Tran to identify transposable element interaction profiles for individual endogenous retrovirus (ERV) families and integration events specific to particular genomes (http://biorxiv.org/cgi/content/short/295329v1). We can now show that TEs participate in both long- and short-range contacts and could potentially be in involved in the regulation of multiple target loci. Thus, we are one of a handful of labs that has expertise in both the experimental and analytical aspects of chromosome folding. My lab shares its knowledge widely with the scientific community both inside and outside of NYU as demonstrated by our numerous collaborative publications (see link to ncbi below).
1997 - 1998 Postdoctoral Research Fellow, Imperial College Medical School, London
1998 - 2002 Postdoctoral Research Fellow, MRC (Medical Research Council), U.K., London
2002 - 2006 Tenured Senior Lecturer, Dept. of Immunology and Molecular Pathology, University College, London
2006 - 2009 Assistant Professor, Dept. of Pathology, NYU School of Medicine, New York, NY
2009 - 2011 Associate Professor, Dept. of Pathology, NYU School of Medicine, New York, NY
2011 - 2014 Associate Professor with tenure, Dept. of Pathology, NYU School of Medicine, New York, NY
2014 - Professor, Dept. of Pathology, New York University School of Medicine, New York, NY
2016 - Director of the Cancer Genome Dynamics program, Perelman Cancer Center, NYU
2017 - Sandra and Edward Meyer Chair of Radiation Oncology
2018 - Affiliate Member New York Genome Center