Nuclear Landscapes

DNA is stored within the small volume of nucleus in each cell of our body. It is wrapped around histone proteins and coiled to form a dense fiber called chromatin. The spatial organization of chromatin 10 nm fiber is that is not random, first chromatin loops are observed, multiple loops form genomic domains (topologically associating domains, or chromatin contact domains), the variety of domains comprise chromosome territories, finally compartments and whole nucleome structure is constructed from those elementary building blocks. The Nuclear Landscapes conference address the basic biophysical properties responsible for such multi-scale organization. Furthermore, we will explore the DNA sequence motifs recognised by the variety of DNA-binding proteins responsible for structural features, such as chromatin looping or borders between genomic domains. The three-dimensional structure of chromatin orchestrate the expression of genes, therefore performing its biological function. The conference aims at providing better understanding the principles of this structural organization in time, following old paradigm known from classical bioinformatics: biopolymer sequence codes its three dimensional structure, which in turn determine biological function. Finally, we will address the fundamental question for personalized medicine, namely how changes in the nuclear organization affect normal development as well as various diseases.